The Central Spine will link Kumasi in the central part of Ghana to Paga, which is in the north, on the border with Burkina Faso. The central Spine is 595km. when developed it would facilitate the transportation of passengers and freight cargo from the South to the North of Ghana and onward to Burkina Faso and the Sahelian Region. At the Kumasi Junction, the Central Line splits into two lines, the Eastern Line and the Western Line. This will lead to a major transformation of the economy.

The Ministry of Railway Development is going through a procurement process to engage consultants to undertake financial, economic, social and environmental; studies as well as surveying and mapping out the right-of-way. The estimated of this line is US$3,332,000.00.