The Eastern Line covers a distance of 300km from Accra to Kumasi with a branch line from Accra to Tema. Apart the 20km Accra-Tema Line and the 40 km Accra-Nsawam Line which are all used for passengers services, the rest of the line is in despair and inoperative.

The town of Kibi is between Accra and Kumasi. Here, significant bauxite deposits of approximately 180 million metric tons may be found. Mt. Ejuanema also on the Eastern Line also connects to the Central Spine which terminates on the border with Burkina Faso at Paga. It has escort potential for significant passengers as well as freight traffic. A proposed inland rail terminal (Boankra Inland Port) also lies on the Eastern Rail Line.